The House of Hanover was the ruling family of Great Britain and Ireland, on Earth, during the 18th and 19th centuries.
Like the leaders of Fendaus V who were without limbs, the House of Hanover also developed a specific genetic defect, which was, in their case, hemophilia. (TNG: "Loud As A Whisper")
In the episode's script, it was the House of Tudor with this specific genetic defect.