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Book

McCune-Albright Syndrome

Leilani Holbrook  1 , Robert Brady  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.
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Book

McCune-Albright Syndrome

Leilani Holbrook et al.
Free Books & Documents

Excerpt

McCune-Albright syndrome is a rare genetic disordered originally recognized by the triad of polyostotic fibrous dysplasia, precocious puberty, and café-au-lait spots. A variety of endocrine disorders, including hyperthyroidism, acromegaly, phosphate wasting, and Cushing syndrome are now considered as part of the endocrinopathies seen in this disorder. The variable constellation of symptoms arises from a somatic activating mutation of the GNAS gene, which is present in many tissue types.

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Conflict of interest statement

Disclosure: Leilani Holbrook declares no relevant financial relationships with ineligible companies.

Disclosure: Robert Brady declares no relevant financial relationships with ineligible companies.

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References

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