Sir, when I realized that time travel may be a problem, I sent one of our best dupes back in time to make sure Beast finished the serum. It won't be a problem. Or it already wasn't since you're still here. 
Appearing in 1st story
Featured Characters:
- Emperor Prime (Jamie Madrox) (Main story and recap)
- Cloak (Jamie Madrox) (Main story and recap) (Origin revealed)
- Hulk (Jamie Madrox) (Main story and recap) (Origin revealed) (Joins and leaves the Hulk Gang)
- Deadpool (Jamie Madrox) (Main story and recap) (Origin revealed) (Joins and leaves the Freakshow)
- Multiple Man (Jamie Madrox)
- Cable (Jamie Madrox) (Main story and recap) (Origin revealed) (Clan Askani)
Supporting Characters:
- X-Men (Main story and recap)
- Beast (Dr. Hank McCoy) (Main story and recap)
- Archangel (Warren Worthington III) (Main story and recap)
- Bishop (Lucas Bishop) (Main story and recap)
- Iceman (Bobby Drake) (Main story and recap)
- Kitty Pryde (Main story and recap)
- Jubilee (Jubes Lee) (Only in recap)
- Nightcrawler (Kurt Wagner) (Main story and recap)
- New Mutants (Main story and recap)
- Magik (Illyana Rasputin) (Main story and recap)
- Strong Guy (Guido Carosella) (Main story and recap)
- Wolfsbane (Rahne Sinclair) (Only in recap)
- Wagner
- Doctor Anthony Stark
- Hawkeye (Clint Barton)
- Hulk Gang
- Charlie Banner
- Otis Banner
- Unidentified others
- Freakshow
- Clan Askani
- Warlock (First appearance chronologically)
Antagonists:
- Lieutenant Jamie Madrox
- Emperor Madrox's NYPD shock troops
- Sentinels
Other Characters:
- Multiple Man (Jamie Madrox) (Corpse, skeleton or other remains)
- Archangel (Warren Worthington III) (Corpse, skeleton or other remains)
- James Madrox (Time-Traveler) (Earth-616)
- God (Yahweh) (Invoked)
- Doctor Strange (Stephen Strange) (Mentioned)
- Iron Man Sentries
- Avengers (Mentioned)
- X-Men (Mentioned)
- Avengers (Mentioned)
- Iron Man (Tony Stark) (Mentioned)
- X-Force (First appearance)
- Cannonball (Samuel Guthrie) (First appearance)
- Rictor (Julio Richter) (First appearance)
- Boom Boom (Tabitha Smith) (First appearance)
- Cable (Nathan Summers) (First appearance)
- Wonder Man (Simon Williams) (First appearance)
- Punisher (Frank Castle) (First appearance)
- X-Men (Mentioned) (Defunct)
- Cloak (Tyrone Johnson) (Mentioned) (Deceased)
- Apocalypse (En Sabah Nur) (Mentioned)
- Weapon Plus (Mentioned)
- Forge (Mentioned)
- Darth Maul (Mentioned) (Topical Reference) (Only in recap)
Races and Species:
- Killcrops (Main story and recap)
- Mutants (Main story and recap)
- Robots
- Humans
- Sentinels
- Moloids
- Technarchy (Main story and recap)
- Dinosaurs
Locations:
- Emperor Madrox Universe
- Earth (2033 A.D.)
- Prime Marvel Universe (Main story and recap)
- Earth (Main story and recap)
- United States of America (Main story and recap)
- New York (Main story and recap)
- New York City (Main story and recap)
- Manhattan (Main story and recap)
- Central Park (Main story and recap)
- Xavier Institute for Mutant Education and Outreach (Main story and recap)
- Central Park (Main story and recap)
- Manhattan (Main story and recap)
- New York City (Main story and recap)
- New York (Main story and recap)
- Kathmandu, Nepal (Mentioned) (Only in recap)
- United States of America (Main story and recap)
- Hell (Invoked)
- Earth (Main story and recap)
- 2099 A.D.
- Wastelands
- 2099 A.D.
- Earth-TRN1084 (First appearance)
- Earth (First appearance)
- Bobbie's Beach Bar (First appearance)
- Earth (First appearance)
Items:
- Soulswords (Main story and recap)
- Emperor Prime's trophies
- Stilt-Man's Battlesuit (Cameo)
- Falcon's Wings (Cameo)
- Grim Reaper's Scythe (Cameo)
- Cloak of Levitation (Cameo)
- Magneto's Helmet (First appearance) (Cameo)
- Web-Shooters (First appearance) (Cameo)
- Numerous unidentified others (Cameo)
- Chronal Beacon (Main story and recap)
- X-Uniforms (Main story and recap)
- Arc Reactor
- Hawkeye's Bow and Trick Arrows
- Techno-Organic Virus
- Cloak's Cloak and Darkforce (Main story and recap)
- Transmode Virus (Main story and recap)
- Deadpool's Suit and Katanas (Main story and recap)
- Lightsaber (Mentioned) (Topical Reference) (Only in recap)
Synopsis for 1st story
- Synopsis not yet written
Solicit Synopsis
THE SECRET HISTORY OF MADROX!
• When you saw many footprints, that was Jamie Madrox... When you saw only one set of footprints, that was still Jamie, but he was carrying the entire Marvel Universe to safety!
• Find out how Multiple Man single-handedly saved the Marvel Universe – past, present and future!